1. Genomic tug of war could boost cancer therapy

    By Science X staff Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time. Wilmot Cancer Institute
  2. The cell's 'read–write' mechanism: Researchers uncover how instructions for gene expression are relayed

    By Science X staff The "read–write" mechanism by which cells replicate and use chemical instructions for expressing genes has been uncovered by RIKEN researchers. The quality and quantity of gene expression correlates not only with instructions by transcription factors but also wi
  3. A known environmental hazard can change the epigenetics of cells

    By Science X staff Epigenetics, the chemical mechanisms that control the activity of genes, allows our cells, tissues and organs to adapt to the changing circumstances of the environment around us. This advantage can become a drawback, though, as this epigenetic regulation can be
  4. Epigenetically acting drugs could support cancer immunotherapy

    By Science X staff Epigenetically active drugs enable the cell to read parts oft he genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the Univers